报告题目: Using aspects of the site frequency spectrum to study demographic history of humans and horses
委员：周忠和 刘武 吴秀杰 同号文 付巧妹
内容简介：The site frequency spectrum characterizes the genetic variation found within different studied populations, providing insight on past demographic history. Here, I describe two methods of studying demographic history that condition or transform the site frequency spectrum to provide greater understanding of demographic history. The doubly conditioned site frequency spectrum helps to highlight differences between admixture and ancient structure models, helping to confirm that Neanderthals did admix with the ancestors of non-African humans. Projection analysis compares a single test genome to a reference population and provides insight on the demographic relationship between the reference and test populations analyzed. I apply this method to human data to better articulate human demographic history and demonstrate the utility of the method. I have also applied it to genomic data from ancient and modern horses, highlighting admixture between the Przewalski's horse and domestic horses, as well as the relationship of several ancient horse genomes to present day horse populations.