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  • 姓名: 付巧妹
  • 性别: 女
  • 职称: 研究员
  • 职务: 脊椎动物演化与人类起源重点实验室副主任,古DNA实验室主任
  • 学历: 博士
  • 电话: 
  • 传真: 010-68357001
  • 电子邮件: fuqiaomei@ivpp.ac.cn
  • 通讯地址: 北京市西城区西直门外大街142号
    简  历:
  •   2007年在西北大学获理学学士学位,2009年在中国科学院研究生院获硕士学位,2013年在德国马克思.普朗克进化人类研究所获演化遗传学博士学位。20101月起,负责中国科学院古脊椎动物与古人类研究所中德人类演化与科技考古联合实验室古DNA平台;先后在德国马普进化人类学研究所和美国哈佛医学院从事博士后研究工作。现为中国科学院古脊椎动物与古人类研究所研究员、脊椎动物演化与人类起源重点实验室副主任、古DNA实验室主任。

        

      目前她在国际核心期刊发表重要论文40余篇,其中高影响论文有31篇(IF大于8),在NatureScienceCell期刊发表20篇,论文总IF超过500,引用次数超过3000次。相关成果入选Nature2014年度十大科学事件”、“2016年度中国古生物学十大进展”等。共同开发的古基因组技术为推动古DNA规模性研究及人类学、演化遗传学等相关领域发展提供助力;破译世界最古老现代人基因组及在其他欧亚人群研究上取得重大突破,帮助重写欧洲最早的现代人类历史及丰富人类演化过程的细节知识;大规模开展中国史前人群的基因组测序与分析,为东亚人群古DNA研究打开局面,且填补了东方史前人类遗传、演化、适应方面的重要信息。因成果显著,她被《Nature》评为“中国十大科学之星”之一,被CCTV评为“中国科技创新人物”之一,入选发展中国家科学院(TWAS)青年通讯院士、国家杰出青年科学基金资助项目,获得“美国HHMI国际青年科学家奖”、“第十五届中国青年科技奖-特别奖项”、腾讯“科学探索奖”,主持科技部国家重点研发计划项目等。  

    社会任职:
  • 《人类学学报》期刊编委、《Human Genomics》期刊编委、《PLOS Biology》期刊编委、《Molicular Biology and Evolution》期刊资深编辑;中国第四纪科学研究会人类演化与环境考古专业委员会副主任。

    研究方向:
  •   主要从事演化遗传及群体遗传方面的研究,重点围绕人类古基因组学研究方向,基于延展应用和共同开发创新的古DNA实验技术,从遗传学角度深入探索人类及其伴生物种的起源与演化历史,阐明欧亚现代人,尤其是东亚人的遗传结构、演化过程、迁徙路径、环境适应及与古人类的基因交流等重要科学问题。 

     

    承担科研项目情况:
    代表论著:
  • 1. Bai F, Zhang X, Ji X, Cao P, Feng X, Yang R, Peng M, Pei S, Fu Q*. Paleolithic genetic link between Southern China and Mainland Southeast Asia revealed by ancient mitochondrial genome. Journal of Human Genetics. 2020 July; (W1). https://doi.org/10.1038/s10038-020-0796-9.

    2. Zhang M, Fu Q*. Human evolutionary history in Eastern Eurasia using insights from ancient DNA. Current Opinion in Genetics & Development. 2020 July;62:78-84.

    3. Ding M, He W, Wang T, Shargan W, Zhang M, Cao P, Liu F, Dai Q, Fu Q*. 中国西藏拉托唐古墓地古代居民线粒体全基因组研究 (A Study of the mithochondrial genome of ancient inhabitants from the Latuotanggu cemetery, Tibet, China). Acta Anthropologica Sinica. 2020 July 15;39(e).

    4. Yang MA, Fan X, Sun B, Chen C, Lang J, Ko Y, Tsang C, Chiu H, Wang T, Bao Q, Wu X, Hajdinjak M, Min-shan Ko A, Ding M, Cao P, Yang R, Liu F, Nickel B, Dai Q, Feng X, Zhang L, Sun C, Ning C, Zeng W, Zhao Y, Zhang M, Gao X, Cui Y, Reich D, Stoneking M, Fu Q*. Ancient DNA indicates human population shifts and admixture in northern and southern China. Science. 2020 May;369(6501):eaba0909.

    5. Zhang M, Sun G, Ren L, Yuan H, Dong G, Zhang L, Liu F, Cao P, Ko AM, Yang MA, Hu S*, Wang GD*, Fu Q*. Ancient DNA evidence from China reveals the expansion of Pacific dogs. Mol Biol Evol. 2020 May 37(5):1462-1469.

    6.  Ding M, Wang T, Min-Shan Ko A, Chen H, Wang H, Dong G, …, Wang H, Yang MA, Fu Q*. Ancient mitogenomes show plateau populations from last 5200 years partially contributed to present-day Tibetans. Proceedings of the Royal Society B: Biological Sciences. 2020 Mar;287(1923):20192968.

    7. Wang GD, Zhang M, Wang X, Yang MA, Cao P, Liu F, Lu H, Feng X, Skoglund P, Wang L, Fu Q*, Zhang YP*. Genomic Approaches Reveal an Endemic Subpopulation of Gray Wolves in Southern China. iScience. 2019 Oct. 25;20:110-118.

    8. Sikora M*, Pitulko VV*, Sousa VC, Allentoft ME, Vinner L, Rasmussen S, Margaryan A, de Barros Damgaard P, de la Fuente C, Renaud G, Yang MA, Fu Q, Dupanloup I, Giampoudakis K, Nogués-Bravo D, …, Meltzer DJ, Excoffier L*, Willerslev E*. The population history of northeastern Siberia since the Pleistocene. Nature. 2019 Jun;570(7760):182-188.

    9. Wang X, Zhou BW, Yang MA, Yin TT, Chen FL, Ommeh SC, Esmailizadeh A, Turner MM, Poyarkov AD, Savolainen P, Wang GD*, Fu Q*, Zhang YP*. Canine transmissible venereal tumor genome reveals ancient introgression from coyotes to pre-contact dogs in North America. Cell Res. 2019 Jul;29(7):592-595.

    10. Chen F*, Welker F, Shen CC, Bailey SE, Bergmann I, Davis S, Xia H, Wang H, Fischer R, Freidline SE, Yu TL, Skinner MM, Stelzer S, Dong G, Fu Q, Dong G, Wang J, Zhang D*, Hublin JJ*. A late Middle Pleistocene Denisovan mandible from the Tibetan Plateau. Nature. 2019 May;569(7756):409-412.

    11. Liu S, Huang S, Chen F, Zhao L, Yuan Y, Francis SS, Fang L, Li Z, Lin L, Liu R, Zhang Y, Xu H, Li S, Zhou Y, Davies RW, Liu Q, Walters RG, Lin K, Ju J, Korneliussen T, Yang MA, Fu Q, Wang J*, Zhou L, Krogh A, Zhang H, Wang W, Chen Z, Cai Z, Yin Y, Yang H, Mao M, Shendure J, Wang J, Albrechtsen A*, Jin X*, Nielsen R*, Xu X*. Genomic Analyses from Non-invasive Prenatal Testing Reveal Genetic Associations, Patterns of Viral Infections, and Chinese Population History. Cell. 2018 Oct 4;175(2):347-359.

    12. Min-Shan Ko A, Zhang Y, Yang MA, Hu Y, Cao P, Feng X, Zhang L, Wei F, Fu Q*. Mitochondrial Genome of a 22,000-year-old Giant Panda from Southern China Reveals a New Panda Lineage. Curr Biol. 2018 Jun 18;28(12):R693-R694.

    13. Zhang M & Fu Q*. 史前古人的基因交流及当今代人的影响 (Prehistoric interbreeding between archaic human groups and anatomically modern humans. Acta Anthropologica Sinica). Acta Anthropologica Sinica. 2018 May;37(2):206-218.

    14. Hajdinjak M*, Fu Q, Hübner A, Petr M, Mafessoni F, Grote S, Skoglund P, Narasimham V, Rougier H, Crevecoeur I, Semal P, Soressi M, …, Meyer M, Paabo S*, Kelso J*. Reconstructing the genetic history of late Neandertals. Nature. 2018 Mar 29;555(7698):652-656.

    15. Yang, M.A & Fu Q*. Insights into Modern Human Prehistory Using Ancient Genomes. Trends in Genetics. 2018 Mar;34(3):184-196. 

    16. Li J, Zeng W, Zhang Y, Ko AM, Li C, Zhu H, Fu Q*, Zhou H*. Ancient DNA reveals genetic connections between early Di-Qiang and Han Chinese. BMC Evol Biol. 2017 Dec 4;17(1):239.

    17. Prüfer K*, de Filippo C, Grote S, Mafessoni F, Korlevic P, Hajdinjak M, Vernot B, Skov L, Hsieh P, Peyrégne S, Reher D, Hopfe C, Nagel S, Maricic T, Fu Q, …, Meyer M, Paabo S*. A high-coverage Neandertal genome from Vindija Cave in Croatia. Science. 2017 Nov 3;358(6363):655-658.

    18. Yang MA, Gao X, Theunert C, Tong H, Aximu-Petri A, Nickel B, Slatkin M, Meyer M, Paabo S, Kelso J*, Fu Q*. 40,000-Year-Old Individual from Asia Provides Insight into Early Population Structure in Eurasia. Curr Biol. 2017 Oct 23;27(20):3202-3208.e9.

    19. Skoglund P*, Posth C, Sirak K, Spriggs M, Valentin F, Bedford S, Clark GR, Reepmeyer C, Petchey F, Fernandes D, Fu Q, Harney E, Lipson M, …, Krause J, Pinhasi R*, Reich D*. Genomic insights into the peopling of the Southwest Pacific. Nature. 2016 Oct 27;538(7626):510-513.

    20. Mallick S*, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F, Zhao M, Chennagiri N, Nordenfelt S, Tandon A, Skoglund P, Lazaridis I, Sankararaman S, Fu Q, Rohland N, …, Patterson N, Reich D*. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature. 2016 Oct 13;538(7624):201-206.

    21. Lazaridis I*, Nadel D, Rollefson G, Merrett DC, Rohland N, Mallick S, Fernandes D, Novak M, Gamarra B, Sirak K, Connell S, Stewardson K, Harney E, Fu Q, Gonzalez-Fortes G, …, Patterson N, Pinhasi R*, Reich D*. Genomic insights into the origin of farming in the ancient Near East. Nature. 2016 Aug 25;536(7617):419-24.

    22. Fu Q, Posth C, Hajdinjak M, Petr M, Mallick S, Fernandes D, Furtwangler A, Haak W, Meyer M, Mittnik A, …, Patterson N, Krause J*, Paabo S*, Reich D*. The genetic history of Ice Age Europe. Nature. 2016 Jun 9;534(7606):200-5.

    23. Moorjani P*, Sankararaman S, Fu Q, Przeworski M, Patterson N, Reich D*. A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years. Proc Natl Acad Sci USA. 2016 May 17;113(20):5652-7.

    24. Kuhlwilm M, Gronau I, Hubisz MJ, de Filippo C, Prado-Martinez J, Kircher M, Fu Q, Burbano HA, Lalueza-Fox C, …, Paabo S, Meyer M, Siepel A*, Castellano S*. Ancient gene flow from early modern humans into Eastern Neanderthals. Nature. 2016 Feb 25;530(7591):429-33.

    25. Key FM, Fu Q, Romagné F, Lachmann M, Andrés AM*. Human adaptation and population differentiation in the light of ancient genomes. Nat Commun. 2016 Mar 18;7:10775.

    26. Fu Q, Hajdinjak M, Moldovan OT, Constantin S, Mallick S, Skoglund P, Patterson N, Rohland N, Lazaridis I, Nickel B, Viola B, Prüfer K, Meyer M, Kelso J, Reich D*, Paabo S*. An early modern human from Romania with a recent Neanderthal ancestor. Nature. 2015 Aug 13;524(7564):216-9.

    27. Fu Q, Li H, Moorjani P, Jay F, Slepchenko SM, Bondarev AA, Johnson PL, Aximu-Petri A, Prüfer K, de Filippo C, Meyer M, …, Hublin JJ, Reich D*, Kelso J*, Viola TB*, Paabo S. Genome sequence of a 45,000-year-old modern human from western Siberia. Nature. 2014 Oct 23;514(7523):445-9.

    28. Haak W, Lazaridis I, Patterson N, Rohland N, Mallick S, Llamas B, Brandt G, Nordenfelt S, Harney E, Stewardson K, Fu Q, Mittnik A, Bánffy E, Alt KW, Reich D*. Massive migration from the steppe was a source for Indo-European languages in Europe. Nature. 2015 Jun 11;522(7555):207-11.

    29. Lazaridis I, Patterson N, Mittnik A, Renaud G, Mallick S, Kirsanow K, Sudmant PH, Schraiber JG, Castellano S, Lipson M, Berger B, Economou C, Bollongino R, Fu Q, Bos KI, …, Paabo S, Kelso J, Reich D*, Krause J*. Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature. 2014 Sep 18;513(7518):409-13.

    30. Castellano S*, Parra G, Sánchez-Quinto FA, Racimo F, Kuhlwilm M, Kircher M, Sawyer S, Fu Q, Heinze A, Nickel B, Dabney J, Siebauer M, White L, …, Andrés AM, Paabo S*. Patterns of coding variation in the complete exomes of three Neandertals. Proc Natl Acad Sci USA. 2014 May 6;111(18):6666-71.

    31. Ko AM, Chen CY, Fu Q, Delfin F, Li M, Chiu HL, Stoneking M*, Ko YC*. Early Austronesians: into and out of Taiwan. Am J Hum Genet. 2014 Mar 6;94(3):426-36.

    32. Prüfer K, Racimo F, Patterson N, Jay F, Sankararaman S, Sawyer S, Heinze A, Renaud G, Sudmant PH, de Filippo C, Li H, Mallick S, Dannemann M, Fu Q, Kircher M, …, Reich D*, Kelso J, Paabo S*. The complete genome sequence of a Neanderthal from the Altai Mountains. Nature. 2014 Jan 2;505(7481):43-9.

    33. Meyer M*, Fu Q, Aximu-Petri A, Glocke I, Nickel B, Arsuaga JL, Martínez I, Gracia A, de Castro JM, Carbonell E, Paabo S. A mitochondrial genome sequence of a hominin from Sima de los Huesos. Nature. 2014 Jan 16;505(7483):403-6.

    34. Benazzi S*, Peresani M, Talamo S, Fu Q, Mannino MA, Richards MP, Hublin JJ. A reassessment of the presumed Neandertal remains from San Bernardino Cave, Italy. J Hum Evol. 2014 Jan;66:89-94.

    35. Fu Q, Mittnik A, Johnson PLF, Bos K, Lari M, Bollongino R, Sun C, Giemsch L, Schmitz R, Burger J, Ronchitelli AM, Martini F, Cremonesi RG, Svoboda J, Bauer P, Caramelli D, Castellano S, Reich D, Paabo S, Krause J*. A revised timescale for human evolution based on ancient mitochondrial genomes. Curr Biol. 2013 Apr 8;23(7):553-559.

    36. Fu Q*, Meyer M, Gao X, Stenzel U, Burbano HA, Kelso J, Paabo S*. DNA analysis of an early modern human from Tianyuan Cave, China. Proc Natl Acad Sci USA. 2013 Feb 5;110(6):2223-7.

    37. Fu Q*, Rudan P, Paabo S, Krause J. Complete mitochondrial genomes reveal neolithic expansion into Europe. PLoS One. 2012;7(3):e32473.

    38. Meyer M*, Kircher M, Gansauge MT, Li H, Racimo F, Mallick S, Schraiber JG, Jay F, Prüfer K, de Filippo C, Sudmant PH, Alkan C, Fu Q, Do R, Rohland N, …, Slatkin M, Reich D*, Kelso J, Paabo S*. A high-coverage genome sequence from an archaic Denisovan individual. Science. 2012 Oct 12;338(6104):222-6.

    39. Reich D*, Green RE, Kircher M, Krause J, Patterson N, Durand EY, Viola B*, Briggs AW, Stenzel U, Johnson PL, Maricic T, Good JM, Marques-Bonet T, Alkan C, Fu Q, …, Slatkin M, Paabo S*. Genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature. 2010 Dec 23;468(7327):1053-60.

    40. Fu Q, Jin S, Hu Y*, Ma Z, Pan J, Wang C. Agricultural development and human diets in Gouwan site, Xichuan, Henan. Chinese Sci Bull. 2010 Mar;55(7): 614-620.

    41. Krause J*, Fu Q, Good JM, Viola B, Shunkov MV, Derevianko AP, Paabo S. The complete mitochondrial DNA genome of an unknown hominin from southern Siberia. Nature. 2010 Apr 8;464(7290):894-7.  

     

    Here * refers to the correspondent author.

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